Estrogen Signaling in Metabolic Inflammation

Figure 1

Estrogen metabolism. The effects of experimental manipulation of enzymes marked in grey boxes modulation are highlighted. Inactivation of aromatase leads to metabolic dysfunction that can be reversed by estrogen replacement. In opposite, estrogen sulfotransferase inactivation in models of obesity or type 2 diabetes mellitus improves metabolic function, an effect that is abolished by ovariectomy. Hepatic expression of steroid sulfatase is induced in animal models of obesity and type 2 diabetes mellitus and seems to alleviate dysmetabolic changes; this effect is also lost with ovariectomy. 17Beta-HSD, 17beta-hydroxysteroid dehydrogenase.