Animal Models of C-Reactive Protein

Table 2

Comparison of CRP in different species.

	Mouse CRP	Rabbit CRP	Human CRP
M.W. (Kd)	19.5	22	21
Plasma levels	<2 mg/L	<3 mg/L; >100 mg/L*	<1 mg/L; >10,000 mg/L*
Activation of complement	No	Yes	Yes
Binding to plasma LDLs	∗∗	Yes	Yes
Deposition in the lesions of atherosclerosis	No	Yes	Yes

∗In acute inflammatory state.
∗∗Wild-type mice do not have LDLs as in humans and rabbits.
Also see [6, 32–38] for details.