CD226 rs763361 Is Associated with the Susceptibility to Type 1 Diabetes and Greater Frequency of GAD65 Autoantibody in a Brazilian Cohort

Table 2

Gender effects on frequency of autoantibodies in T1D patients and controls.

Characteristics	T1D^a patients		Controls		𝑃
	Female	Male	Female	Male
Anti-GAD65^b	48.2%	38.0%	0.9%	1.6%	0.82
Anti-IA2^c	40.2%	45.6%	1.8%	1.9%	0.66
Anti-TPO^d	25.9%	20.2%	19.8%	9.0%	<0.005
Anti-Tg^e	24.5%	23.2%	15.3%	4.0%	<0.005
ANA^f	22.8%	18.5	25.0%	3.2%	<0.05
TRAb^g	5.1%	7.9%	9%	0%	<0.05
Anti-gastric parietal cell	9.2%	1.5%	0%	0.4%	0.91
Anti-21 hydroxylase	5.7%	4.8%	0%	1.1%	0.37
Anti-smooth muscle	3.0%	3.1%	1.6%	0.3%	0.35
Rheumatoid factor	3.9%	1.3%	0%	1.1%	0.78
Anti-LKM-1^h	0.9%	0%	0%	0.4%	1.00

^aT1D: type 1 diabetes; ^bAntiGAD65: glutamic acid decarboxylase antibody; ^cAnti-IA2: tyrosine phosphatase antibody; ^dAnti-TPO: anti- peroxidase antibody; ^eAnti-Tg: anti-thyroglobulin antibody; ^fANA: anti-nuclear antibodies; ^gTRAb: TSH receptor antibody; ^hAnti-LKM-1: anti- liver/kidney microsomal type 1 antibody. The critical 𝑃 values for the lines where the samples are separated by gender are for gender effect only in a nominal logistic fit. 𝑃was corrected by Bonferroni's criterium <0.0045.