CD226 rs763361 Is Associated with the Susceptibility to Type 1 Diabetes and Greater Frequency of GAD65 Autoantibody in a Brazilian Cohort

Table 5

Frequency of autoantibodies in pooled sample of patients and controls according to gender and CD226 rs763361 genotypes.

Autoantibody	Females		𝑃 value	Males		𝑃 value
	TT	CT/CC		TT	CT/CC
Anti-GAD^a	35.9	21.7	0.0015	13.6	12.9	0.89
Anti-IA2^b	28.8	18.8	0.02	13.1	16.2	0.42
Anti-Gastric Parietal cell	10.6	3.9	0.53	0.0	1.0	1.00
Anti-smooth muscle	3.9	3.5	1.00	0.9	1.3	1.00
Anti-LKM-1^c	0.0	1.3	1.00	0.0	0.5	1.00
Anti-21-hidroxilase	4.8	2.8	0.62	2.3	2.7	1.00
ANA^d	24.2	22.1	0.85	9.0	6.1	0.35
Rheumatoid Factor	0.0	6.0	0.08	0.0	1.7	0.58
Anti-TPO^e	25.0	22.6	0.66	13.2	11.3	0.61
Anti-Tg^f	23.2	18.3	0.36	10.5	8.4	0.56
TRAB^g	5.9	5.1	1.00	3.2	0.9	0.14

^aAntiGAD65: glutamic acid decarboxylase antibody; ^bAnti-IA2: tyrosine phosphatase antibody; ^cAnti-LKM-1: anti-liver/kidney microsomal type 1 antibody; ^dANA: anti-nuclear antibody; ^eAnti-TPO: anti-peroxidase antibody; ^fAnti-Tg: anti-thyroglobulin antibody; ^gTRAb: TSH receptor antibody. 𝑃 values were determined by the Fisher exact test; critical 𝑃 was corrected by the Bonferroni’s method <0.0045.