A3 Adenosine Receptor Allosteric Modulator Induces an Anti-Inflammatory Effect: In Vivo Studies and Molecular Mechanism of Action

<div>LUF6000 downregulates the NF-κB signaling pathway via the A3AR. Protein analysis was performed using Western blot (WB) analysis in both PAW and PBMCs. LUF6000 downregulates A3AR expression levels in both PAW and PBMCs (a). PI3K, IKK, IκB, and NF-κB, all members of the NF-κB signaling pathway, were downregulated upon LUF6000 administration (b).</div>

Mediators of Inflammation

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Figure 3: A3 Adenosine Receptor Allosteric Modulator Induces an Anti-Inflammatory Effect: In Vivo Studies and Molecular Mechanism of Action