A3 Adenosine Receptor Allosteric Modulator Induces an Anti-Inflammatory Effect: In Vivo Studies and Molecular Mechanism of Action

<div>LUF6000 down-regulates the A3AR and key inflammatory proteins. Protein analysis was performed using WB analysis. LUF6000 downregulates A3AR expression levels in the PBMCs of OA-induced rats (a). Jak-2 and STAT-1 were downregulated upon LUF6000 administration (b).</div>

Mediators of Inflammation

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Figure 5

Figure 5: A3 Adenosine Receptor Allosteric Modulator Induces an Anti-Inflammatory Effect: In Vivo Studies and Molecular Mechanism of Action