Effect of Sipjeondaebo-Tang on Cancer-Induced Anorexia and Cachexia in CT-26 Tumor-Bearing Mice
Figure 1
Schedules for prevention and therapy models of mouse cancer-induced cachexia. CT-26 tumor cells were subcutaneously (s.c.) injected into the right flank of BALB/c mice. (a) Experiment method on the prevention: a day after tumor cell inoculation, three doses of SJDBT (L-SJDBT of 6.784 mg/kg, M-SJDBT of 67.84 mg/kg, and H-SJDBT of 678.4 mg/kg) were p.o. administrated daily for 21 days. At 22 days after tumor cell injection, mice were sacrificed. (b) Experiment method on the therapy: 21 days after tumor cell inoculation (a day when cachexia was held), three different doses of SJDBT (L-SJDBT of 6.784 mg/kg, M-SJDBT of 67.84 mg/kg, and H-SJDBT of 678.4 mg/kg) were p.o. administrated daily for 21 days. At the end of experiments (42 days after tumor cell injection), mice were sacrificed.
