Inhibition of Ocular Aldose Reductase by a New Benzofuroxane Derivative Ameliorates Rat Endotoxic Uveitis

<div>Representative immunohistochemistry for nitrotyrosine, CD117-ckit, and CD34 in the eye structures of rats treated with vehicle, LPS, and BF-5m (0.05 <i>μ</i>M/rat). Intravitreal BF-5m increases CD34<sup>+</sup> and CD117<sup>+</sup> immunostaining into the eye, while reducing the nitrotyrosine. Nitro: nitrotyrosine; R: retina; Ch: choroid; Cb: ciliary bodies. Scale bar, 50 <i>μ</i>m. 200x magnification.</div>

Mediators of Inflammation

fig7

Figure 7

Figure 7: Inhibition of Ocular Aldose Reductase by a New Benzofuroxane Derivative Ameliorates Rat Endotoxic Uveitis 