Predictive Criteria to Study the Pathogenesis of Malaria-Associated ALI/ARDS in Mice
Figure 5
A murine model to predict malaria-associated ALI/ARDS. (a) Penh (enhanced pause), (b) respiratory frequency, and (c) parasitemia measured on the 7th DAI. The sacrificed mice were classified according predictive model, using the parameter cut-offs measured from the survival mice and applied to the sacrificed mice. DBA/2 mice infected with P. berghei ANKA and their breathing parameters were measured in plethysmograph chambers (BUXCO Electronics, USA). Note that these three parameters are similar between the survival group and sacrificed group; ( mice/group; , , Mann-Whitney test). ALI/ARDS: acute lung injury/acute respiratory distress syndrome; HP: hyperparasitemia; bpm: beats per minute. Results are representative of more than 5 independent experiments.
