Expression of IL-18, IL-18 Binding Protein, and IL-18 Receptor by Normal and Cancerous Human Ovarian Tissues: Possible Implication of IL-18 in the Pathogenesis of Ovarian Carcinoma
Figure 2
IL-18, IL-18BP, and IL-18R mRNA levels in normal and cancerous ovarian homogenates. Normal and cancerous ovarian samples were homogenized. The expression levels of IL-18 (a), IL-18BP (b), and IL-18R (c) mRNA were evaluated by semiquantitative RT-PCR. Quantitative evaluation of the positive PCR products was performed by densitometry. Each point represents the ratio between IL-18, IL-18BP, or IL-18R bands and -actin bands of the same sample; and 10 in (a), 12 and 10 in (b), and 10 and 7 in (c), for the normal and carcinoma samples, respectively. Horizontal lines indicate MEAN ± SEM. (d) Representative samples of normal (1–4) and cancerous (5–8) ovarian tissues are presented. indicates statistical significance according to -test: .
