Hydrogen Sulfide Ameliorates Ischemia/Reperfusion-Induced Hepatitis by Inhibiting Apoptosis and Autophagy Pathways

<table>NaHS pretreatment inhibits the release of cytokines during hepatic ischemia-reperfusion (I/R) injury. (a) The mRNA expression of IL-6 and TNF-<i>α</i> in liver tissues was detected by real time PCR. <svg height="17.825001" id="M33" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> for saline versus saline + I/R, <svg height="19.65" id="M34" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 70.224998 19.65" width="70.224998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> for saline + I/R versus I/R + NaHS (14 <i>μ</i>mol/kg). (b) Western blots and quantitative evaluation of the expression of IL-6 and TNF-<i>α</i> in liver tissues with <svg height="16.6625" id="M35" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 10 16.6625" width="10" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,12.162)"><path d="M558 587q0 -32 -14 -61t-40 -53.5t-48.5 -41t-54.5 -36.5q144 -51 144 -174q0 -55 -43.5 -108t-104.5 -87q-77 -42 -131 -42q-31 0 -54 20t-31 47l11 18q48 -29 108 -29q79 0 119.5 43t40.5 109t-44.5 107.5t-119.5 50.5l22 47q34 1 65 21q96 61 96 157q0 42 -24 67.5
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</svg>-actin as protein loading control. <svg height="17.825001" id="M36" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> for saline versus saline + I/R, <svg height="19.65" id="M37" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 70.224998 19.65" width="70.224998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> for saline + I/R versus I/R + NaHS (14 <i>μ</i>mol/kg). (c) Immunohistochemistry staining (200x) showed the expression of TNF-<i>α</i> and IL-6 in liver tissue at 12 h. <svg height="17.825001" id="M38" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> for (<svg height="15" id="M39" style="vertical-align:-0.51414pt" version="1.1" viewbox="0 0 80.212502 15" width="80.212502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) versus (I/R + NaHS).</table>

Mediators of Inflammation

fig3

Figure 3

Figure 3: Hydrogen Sulfide Ameliorates Ischemia/Reperfusion-Induced Hepatitis by Inhibiting Apoptosis and Autophagy Pathways 