Cytokines as Mediators of Pain-Related Process in Breast Cancer

Table 1

Cytokine/chemokine	Role in breast-cancer-related pain	Reference
TGF-β	Major regulator of osteoclasts, affecting bone resorption and osteolysis	[15]
		[18]
		[17]
IL1R1 polymorphism	Patients carrying the minor allele for a single nucleotide polymorphism (SNP) in IL1R reported less pain before breast surgery	[23]
IL1R2 polymorphism	The SNP rs11674595 is associated with the occurrence of persistent breast pain after surgery	[24]
IL13 polymorphism	Women carrying the minor allele for a SNP in IL13 reported significant pain prior to breast surgery	[23]
IL10 gene haplotype	The haplotype A8 is associated with the occurrence of persistent breast pain after surgery	[24]
CCL3	Paclitaxel-mediated pain	[25]
CCR2	Paclitaxel-mediated pain	[26]
CX3CL1	Paclitaxel-mediated pain	[27]
IL10 (serum)	Paclitaxel-induced joint pain	[28]
G-CSF	Muscle pain	[29]