Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis

Figure 2

Increased numbers of cDC and pDC expressing the migratory molecules, CD62L and CCR5, upon one exercise bout. The migratory profile of DC was assessed by enumerating cDC and pDC expressing CD62L and CCR5 in healthy controls (green dots) and MS patients (red dots). Results are shown as mean absolute number ± SEM. Significance () in the complete population of both patients and controls is annotated by black lines. Abbreviations used are as follows: MS: multiple sclerosis; cDC: conventional dendritic cells; pDC: plasmacytoid dendritic cells; CD62L: CD62 ligand; CCR: C-C chemokine receptor; before: measurement before the exercise test; after: measurement immediately after the test; 2 h: measurement 2 hours after the test; and SEM: standard error of the mean.