Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice

Figure 1

Effect of NAC on ConA-induced autoimmune hepatitis. (a) Effects of NAC on plasma ALT and AST levels at 6 h, 12 h, and 24 h after ConA injection in BALB/c mice. Data are expressed as mean ± SD (; for ConA versus NAC 30 min (post-NAC-treated, 30 min after injection with ConA); for NAC 30 min (post-NAC-treated, 30 min after injection with ConA) versus NAC 2 h (NAC-pretreated, 2 h before injection with ConA)). (b) Photomicrographs of representative livers collected 6, 12, and 24 h after ConA injection and stained with hematoxylin and eosin (H&E), ×200 magnification. (c) Effects of NAC on plasma ALT and AST levels at 6 h, 12 h, and 24 h after ConA injection in C57 mice. Data are expressed as mean ± SD (; for ConA versus control group; for ConA versus NAC 2 h (NAC-pretreated, 2 h before injection with ConA)). (d) In C57 mice, photomicrographs of representative livers collected 6, 12, and 24 h after ConA injection and stained with hematoxylin and eosin (H&E), ×200 magnification.

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