Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes

Figure 5

Effect of cGAS silencing on TNFα-induced inflammatory responses in RA FLS. (a) FLS infected with cGAS shRNA produced significantly lower amounts of IL-1β, IL-6, MMP-1, and MMP-3 than did FLS infected with control () when exposed to TNFα stimulation for 30 min. (b) Knockdown of cGAS significantly reduced TNFα-mediated ERK1/2 and AKT phosphorylation by Western blotting in the presence of TNFα stimulation for 30 min.

(a)

(b)