Quantitative In Vivo Detection of Chlamydia muridarum Associated Inflammation in a Mouse Model Using Optical Imaging

Figure 3

Elastase680 is able to distinguish between nonvaccinated and vaccinated animals. (a) Ex vivo ROI analysis on the ovary area of reproductive tracts (/group) 14 days after challenge. At 14 days there was a statistically significant difference between vaccinated animals and naïve (nonvaccinated) animals. (b) At the indicated time points mice (/group) were imaged in vivo and analysis on the ovary region was performed as described in Figure 2. At day 10 there was a statistically significant difference between mock-challenged and naïve/challenged groups only while on day 14 there was a significant difference in both mock-challenged and vaccinated groups versus naïve/challenged group. ; .

(a)

(b)