Reduced Serum Butyrylcholinesterase Activity Indicates Severe Systemic Inflammation in Critically Ill Patients

Figure 1

Reduced BChE activity in patients with systemic inflammation. (a) Scatter plots represent results of BChE point-of-care-testing (POCT) obtained from healthy volunteers (gray open circles, control) and patients diagnosed with systemic inflammation (gray closed circles, see Table 1). (b) Based on subsequent 28-day-survival analysis, patients were further divided into the survivor and nonsurvivor subgroups (black open and closed circles, resp.). ((c)–(h)) Histograms represent concurrent measurements of inflammation biomarkers CRP ( measurements (c)), PCT ( measurements (d)) and WBCC ( measurements (e)) and disease severity scores (SAPS II, SOFA, and APACHE II, measurements each (f), (g), and (h)) from survivors (open circles) and nonsurvivors (closed circles). Bars are median values. , , and (Mann-Whitney test). BChE: butyrylcholinesterase; CRP: C-reactive protein; PCT: procalcitonin; WBCC: white blood cell count; SAPS: simplified acute physiology score; SOFA: sequential organ failure assessment; APACHE: acute physiology and chronic health evaluation.

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