Response to Infliximab in Crohn’s Disease: Genetic Analysis Supporting Expression Profile

Table 2

Genotype frequencies of the polymorphisms located in the genes studied in Crohn’s disease patients: both responders and nonresponders to infliximab.

	Responders		Nonresponders
		%		%
Gene S100A9
rs11205276
GG	189	67	39	67
GC	88	31	18	31
CC	4	2	1	2
rs3014866
CC	94	33	22	37
CT	129	46	30	51
TT	58	21	7	12
Gene S100A12
rs724781
CC	128	46	27	47
CG	115	41	27	47
GG	37	13	4	6
Gene S100A8
rs3006488
AA	235	83	47	78
AG	44	15	12	20
GG	5	2	1	2
Gene G0S2
rs4844486
CC	145	52	33	54
CA	115	42	26	43
AA	18	6	2	3
rs1473683
GG	269	97	54	95
GT	7	3	3	5
TT	0	0	0	0
GENE TNFAIP6
rs11677200^*
TT	79	29	26	45
TC	153	56	24	41
CC	42	15	8	14
rs2342910
AA	138	52	30	57
AT	113	42	18	34
TT	16	6	5	9
rs3755480
GG	218	78	44	72
GA	57	20	15	25
AA	6	2	2	3
rs10432475
AA	224	80	44	77
AG	54	19	12	21
GG	2	1	1	2
Gene IL11
rs1126760
TT	165	60	28	52
TC	94	34	24	44
CC	16	6	2	4
rs1042506
TT	195	76	37	77
TG	52	20	11	23
GG	9	4	0	0

CC genotype, P = 0.017; OR (95% CI) = 0.5 (0.27–0.93).