Comprehensive Screening of Gene Function and Networks by DNA Microarray Analysis in Japanese Patients with Idiopathic Portal Hypertension

Table 2

Top 25 canonical pathways associated with IPH in Ingenuity iReport.

Number	Pathways	DEGs	value	Genes
1	Primary immunodeficiency signaling	4	0.000120085	ADA, CD79A, IGHD, IGLL1/IGLL5
2	Altered T-cell and B-cell signaling in rheumatoid arthritis	4	0.000772903	CD28, SLAMF1, TGFB1, CD79A
3	T-helper cell differentiation	3	0.004440048	CD28, TGFB1, TNFRSF11B
4	Cyclins and cell cycle regulation	3	0.006251755	TGFB1, CDK7, E2F5
5	B-cell development	2	0.010284999	CD79A, IGHD
6	Leukocyte extravasation signaling	4	0.013183985	CXCR4, CD44, MLLT4, MMP12
7	Atherosclerosis signaling	3	0.019146088	TGFB1, CXCR4, PLA2G10
8	Arachidonic acid metabolism	3	0.021798453	GPX3, PLA2G10, CYP4F3
9	Colorectal cancer metastasis signaling	4	0.027547337	RHOQ, TGFB1, PTGER2, MMP12
10	Aryl hydrocarbon receptor signaling	3	0.028201448	TGFB1, NFIA, GSTA5
11	Hepatic fibrosis/hepatic stellate cell activation	3	0.029806364	TGFB1, EDNRA, TNFRSF11B
12	Glioma invasiveness signaling	2	0.030646264	RHOQ, CD44
13	Glutathione metabolism	2	0.031643803	GPX3, GSTA5
14	Cell cycle: G1/S checkpoint regulation	2	0.03367696	TGFB1, E2F5
15	Eicosanoid signaling	2	0.03367696	PLA2G10, PTGER2
16	Induction of apoptosis by HIV1	2	0.03367696	CXCR4, TNFRSF11B
17	Hypoxia signaling in the cardiovascular system	2	0.037891658	UBE2D2, HIF1AN
18	Tight junction signaling	3	0.038540606	TGFB1, MLLT4, TNFRSF11B
19	Germ cell-sertoli cell junction signaling	3	0.039164578	RHOQ, TGFB1, MLLT4
20	Mitotic roles of Polo-like kinase	2	0.040070987	TGFB1, PTTG1
21	Purine metabolism	4	0.043235613	ENTPD4, ABCC1, ADA, SEPT1
22	Endothelin-1 signaling	3	0.046366635	PLA2G10, EDNRA, PTGER2
23	Regulation of IL-2 expression in activated and anergic T Lymphocytes	2	0.05532422	CD28, TGFB1
24	Chronic myeloid leukemia signaling	2	0.073630475	TGFB1, E2F5
25	HMGB1 signaling	2	0.075004378	RHOQ, TNFRSF11B

Underlined genes indicate increases in expression. Not underlined genes indicate decreases in expression.
DEGs: differentially expressed genes.