Downregulation of mPGES-1 Expression via EGR1 Plays an Important Role in Inhibition of Caffeine on PGE₂ Synthesis of HBx(+) Hepatocytes

Figure 1

Effect of caffeine on hepatocyte proliferation and synthesis of PGE₂. ((a) and (b)) Cell proliferation at different caffeine concentrations (0, 200, 400, and 800 μM) and different caffeine treatment days (1, 4, and 7 days). The group data represent the mean ± SD (); denotes a statistically significant difference (); # denotes a statistically significant difference (). ((c) and (d)) PGE₂ level in the supernatant of different cells in caffeine treatment (800 μM) for 7 days. The group data represent the mean ± SD (); denotes a statistically significant difference (); # denotes a statistically significant difference ().

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