5′-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain Ischemia/Reperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response
Table 1
5′-AMP reduces body temperature, heart rate and blood pressure.
Veh
AMP(1.0)
AMP(0.5)
AMP(0.25)
Before AIH
pH
7.44 ± 0.04
7.45 ± 0.07
7.43 ± 0.03
7.44 ± 0.05
pCO2 (mmHg)
35.67 ± 1.61
36.22 ± 4.12
38.22 ± 5.12
37.16 ± 4.19
pO2 (mmHg)
106.42 ± 10.29
110.32 ± 10.12
108.24 ± 8.13
105.34 ± 6.17
Glucose (mg/dL)
118.19 ± 7.24
121.21 ± 12.14
119.34 ± 7.03
129.29 ± 8.44
Hemoglobin (g/dL)
16.25 ± 1.21
15.63 ± 0.91
16.37 ± 0.53
16.12 ± 0.64
MABP (mmHg)
86.12 ± 7.15
85.33 ± 11.12
78.56 ± 12.33
83.82 ± 11.41
HR (beats/min)
378.33 ± 72.33
387.21 ± 52.11
383.09 ± 51.32
362.34 ± 54.76
Temp rect (°C)
36.5 ± 0.11
36.9 ± 0.12
36.7 ± 0.05
36.9 ± 0.03
During AIH
pH
7.41 ± 0.05
7.39 ± 0.12
7.38 ± 0.11
7.40 ± 0.08
pCO2 (mmHg)
41.22 ± 6.11
42.21 ± 3.15
41.38 ± 3.39
41.11 ± 5.19
pO2 (mmHg)
93.16 ± 5.61
98.12 ± 7.23
96.11 ± 5.14
99.21 ± 10.26
Glucose (mg/dL)
109.17 ± 5.64
104.73 ± 7.27
98.24 ± 10.24
116.19 ± 11.24
Hemoglobin (g/dL)
18.41 ± 2.15
19.12 ± 1.52
17.22 ± 5.51
19.22 ± 3.64
MABP (mmHg)
79.81 ± 8.61
71.12 ± 10.52
73.17 ± 8.72
78.21 ± 7.21
HR (beats/min)
358.14 ± 53.12
193.38 ± 42.32*#&
298.24 ± 61.19
332.34 ± 55.22
Temp rect (°C)
36.69 ± 1.39
16.72 ± 1.56*#&
34.15 ± 2.11
36.61 ± 1.95
After AIH
pH
7.41 ± 0.05
7.40 ± 0.03
7.39 ± 0.06
7.41 ± 0.03
pCO2 (mmHg)
38.02 ± 3.18
35.29 ± 4.21
40.21 ± 3.51
36.21 ± 1.18
pO2 (mmHg)
106.76 ± 8.43
115.82 ± 5.92
109.43 ± 9.21
116.24 ± 10.31
Glucose (mg/dL)
110.63 ± 7.92
109.21 ± 10.34
115.41 ± 13.24
117.95 ± 12.95
Hemoglobin (g/dL)
15.33 ± 1.15
16.44 ± 1.62
16.15 ± 1.71
15.72 ± 0.93
MABP (mmHg)
73.12 ± 12.31
71.32 ± 11.35
72.92 ± 4.95
73.14 ± 11.2
HR (beats/min)
364.21 ± 42.42
327.51 ± 32.23
352.01 ± 43.22
356.21 ± 43.25
Temp rect (°C)
36.52 ± 0.11
35.91 ± 0.12
36.71 ± 0.05
36.92 ± 0.03
MABP: mean arterial blood pressure; HR: heart rate; Temp rect: rectal temperature. Values are mean ± SEM, = 9 in each group. *P < 0.05 compared to Veh group, #P < 0.05 compared to AMP(0.5) group and &P < 0.05 compared to AMP(0.25) group.
