Differential Associations between CDH13 Genotypes, Adiponectin Levels, and Circulating Levels of Cellular Adhesive Molecules

Table 1

Baseline characteristics of the health of study participants.

	Total	Men	Women	value
Number	530	270	260
Age (years)	44.9 ± 9.4	43.9 ± 9.3	45.9 ± 9.3	0.013
Body mass index (kg/m^2)	24.2 ± 3.5	24.8 ± 3.2	23.5 ± 3.7	2.2 × 10^−5
Waist circumference (cm)	84.6 ± 9.7	87.4 ± 7.8	81.61 ± 10.5	1.6 × 10^−12
Hypertension	9.6%	8.9%	10.4%	0.331
Diabetes mellitus	2.5%	2.6%	2.3%	0.528
Obesity	36.6%	44.1%	28.8%	1.9 × 10^−4
Adiponectin (mg/L)	7.25 ± 4.90	5.45 ± 3.44	9.13 ± 5.45	7.8 × 10^−21
CRP (mg/L)	1.04 ± 1.35	1.09 ± 1.40	0.99 ± 1.31	0.060
Fibrinogen (mg/dL)	262.6 ± 68.9	260.3 ± 70.9	265.0 ± 66.9	0.432
sE-selectin (ng/mL)	52.7 ± 25.6	60.0 ± 26.8	45.0 ± 21.8	4.1 × 10^−14
sP-selectin (ng/mL)	136.9 ± 115.0	149.8 ± 128.9	123.6 ± 97.0	0.004
sVCAM1 (ng/mL)	488.1 ± 132.7	491.4 ± 153.0	484.86 ± 108.0	0.724
sICAM1 (ng/mL)	241.0 ± 112.8	245.6 ± 109.7	236.1 ± 116.0	0.215
sTNFR2 (pg/mL)	3240.4 ± 922.4	3308.8 ± 969.1	3169.5 ± 867.7	0.082
MCP1 (pg/mL)	73.5 ± 60.6	80.0 ± 70.7	66.8 ± 47.1	0.011
IL6 (pg/L)	4.1 ± 7.6	4.4 ± 9.0	3.9 ± 5.8	0.569
MMP1 (pg/mL)	483.8 ± 1201.4	351.9 ± 585.6	620.2 ± 1597.2	0.850
MMP2 (ng/mL)	126.0 ± 40.9	122.4 ± 41.8	129.8 ± 39.6	0.038
MMP9 (ng/mL)	143.7 ± 112.5	156.7 ± 114.4	130.3 ± 109.2	0.008
SAA (mg/L)	5.90 ± 15.42	6.68 ± 19.64	5.10 ± 9.32	0.374

CRP: C-reactive protein; sE-selectin: soluble E-selectin; sP-selectin: soluble P-selectin; sVCAM1: soluble vascular cell adhesion molecule-1; sICAM1: soluble intercellular adhesion molecule-1; TNFR2: tumor necrosis factor-alpha receptor 2;  MCP1: monocyte chemotactic protein-1; IL6: interleukin-6; MMP1: matrix metalloproteinase-1; MMP2: matrix metalloproteinase-2; MMP9: matrix metalloproteinase-9; SAA: serum amyloid A. Continuous variables are presented as mean ± SD.
CRP: patients with CRP levels >10 mg/L excluded.