CD137 Regulates NFATc1 Expression in Mouse VSMCs through TRAF6/NF-κB p65 Signaling Pathway

Figure 1

TNF-α stimulates CD137 expression in VSMCs. The VSMCs were treated with TNF-α (10 ng/mL) for different times. (a) The cells were harvested at 0, 4, 8, 12, and 24 h after treatment with TNF-α for examination of CD137 mRNA levels by qRT-PCR. (b) The expression of membrane CD137 was examined by FCM ((1) control, (2) stimulated 12 h by TNF-α, (3) stimulated 24 h by TNF-α, and (4) stimulated 36 h by TNF-α). versus control; .

(a)

(b)