Clinical Study
Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation
Table 3
Clinical and laboratory variables associated with vascular disease occurrence.
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Clinical characteristics | AF patients, | SR controls, | Incident VD (−)
(72.0) | Incident VD (+)
(28.0) | HR (95% CI) | value | Incident VD (−)
(88.6) | Incident VD (+)
(11.4) | HR (95% CI) | value |
| | Age at inclusion (years) | 46.2 ± 12.1 | 54.7 ± 7.3 | 1.15 (1.05–1.38) | 0.013 | 46.3 ± 7.8 | 58.6 ± 4.7 | 1.25 (1.13–4.88) | 0.006 | | Time since AF diagnosis (months) | 24 (12–102) | 60 (24–108) | 1.14 (1.04–2.34) | 0.019 | — | — | — | — | | Systolic BP at inclusion (mmHg) | 117.7 ± 9.1 | 128.6 ± 7.6 | 1.10 (1.04–1.17) | 0.002 | 114.6 ± 7.9 | 127.6 ± 7.8 | 1.50 (1.12–2.78) | >0.001 | | Diastolic BP at inclusion (mmHg) | 74.7 ± 5.8 | 78.9 ± 3.5 | 1.16 (1.03–1.32) | 0.018 | 73.6 ± 7.8 | 80.1 ± 3.5 | 1.78 (1.23–3.76) | >0.001 | | BMI (kg/m2) | 24.8 ± 3.4 | 26.8 ± 2.9 | 1.17 (1.01–1.37) | 0.040 | 22.6 ± 2.5 | 23.8 ± 1.9 | 1.15 (0.89–1.78) | 0.116 | | Fibrinogen (g/L) | 3.2 ± 1.0 | 3.7 ± 0.8 | 1.59 (1.13–2.53) | 0.043 | 2.9 ± 1.0 | 3.1 ± 0.7 | 1.13 (0.95–1.89) | 0.221 | | Total cholesterol (mmol/L) | 3.6 ± 0.8 | 4.4 ± 0.8 | 1.99 (1.67–3.38) | 0.011 | 3.8 ± 1.4 | 4.7 ± 1.3 | 2.11 (1.55–4.67) | 0.001 | | LDL-C (mmol/L) | 3.2 ± 0.5 | 3.8 ± 0.6 | 2.28 (1.23–4.21) | 0.008 | 3.0 ± 0.8 | 3.9 ± 1.2 | 2.15 (1.66–3.78) | 0.004 |
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AF: atrial fibrillation; SR: sinus rhythm; HR: hazard ratio; CI: confidence interval; BP: blood pressure; BMI: body mass index; LDL-C: low density lipoprotein cholesterol.
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