Serum Osteocalcin Is Associated with Inflammatory Factors in Metabolic Syndrome: A Population-Based Study in Chinese Males

Table 4

Multivariant-adjusted association between log (osteocalcin) and log (hsCRP) and log (IgE) in subgroups.

		OCN	hsCRP			IgE
		Median	β	(95% CI)		β	(95% CI)
Metabolic syndrome
No (<3 components)	1851	23.42 (19.15–29.18)	−0.009	(−0.020, 0.002)	0.093	−0.02	(−0.027, −0.008)	<0.001
Yes (≧3 components)	192	19.63 (16.75–23.67)	−0.046	(−0.088, −0.004)	0.032	0.002	(−0.029, 0.033)	0.893
Hypertriglyceridemia
No (TG <1.7 mmol/L)	1481	23.81 (19.47–29.46)	−0.01	(−0.021, 0.002)	0.096	−0.02	(−0.030, −0.009)	<0.001
Yes (TG ≧1.7 mmol/L)	562	21.03 (17.53–26.07)	−0.021	(−0.046, 0.006)	0.126	−0	(−0.021, 0.015)	0.747
Hyperglycemia
No (GLU <5.6 mmol/L)	1492	23.71 (19.525–29.41)	−0.003	(−0.015, 0.009)	0.608	−0.02	(−0.030, −0.009)	<0.001
Yes (GLU ≧5.6 mmol/L)	551	21.03 (17.57–26.34)	−0.039	(−0.059, −0.018)	<0.001	−0.01	(−0.025, 0.011)	0.454
Elevated BP
No (<130/85 mmHg)	1838	23.37 (19–29.09)	−0.013	(−0.024, −0.002)	0.022	−0.02	(−0.025, −0.006)	0.001
Yes (≧130/85 mmHg)	205	20.81 (17.39–25.68)	−0.006	(−0.040, 0.029)	0.752	−0.02	(−0.046, 0.008)	0.167
Low HDL-c
No (≧1.03 mmol/L)	1894	23.22 (18.84–29.04)	−0.011	(−0.021, 0.001)	0.057	−0.02	(−0.026, −0.007)	<0.001
Yes (<1.03 mmol/L)	149	20.92 (18.47–24.05)	−0.014	(−0.055, 0.023)	0.488	−0	(−0.043, 0.039)	0.928
Central obesity
No (WC <90 cm)	1687	23.64 (19.45–29.39)	−0.01	(−0.021, 0.001)	0.075	−0.02	(−0.026, −0.006)	0.002
Yes (WC ≧90 cm)	356	19.86 (16.84–24.88)	−0.022	(−0.052, 0.008)	0.158	−0.01	(−0.032, 0.012)	0.365
Obesity according to BMI
<27.5 kg/m^2	1821	23.38 (19.07–29.14)	−0.009	(−0.020, −0.002)	0.096	−0.02	(−0.025, −0.006)	0.002
≧27.5 kg/m^2	222	20.69 (16.6–24.37)	−0.039	(−0.075, −0.002)	0.039	−0.01	(−0.038, 0.015)	0.394
Premetabolic syndrome
None	967	25.17 (20.67–31.27)	<0.001	(−0.015, 0.014)	0.945	−0.02	(−0.031, −0.005)	0.005
1 component	574	22.21 (18.07–27.57)	−0.031	(−0.051, −0.012)	0.002	−0.02	(−0.037, −0.003)	0.02
≧2 components	310	20.61 (17.38–24.91)	0.002	(−0.030, 0.034)	0.892	−0.01	(−0.030, 0.018)	0.623
Prediabetes
NGT (GLU <5.6 mmol/L)	1796	23.71 (19.53–29.41)	−0.004	(−0.016, 0.008)	0.529	−0.02	(−0.029, −0.008)	<0.001
IFG (GLU = 5.6–7.0 mmol/L)	558	21.43 (17.94–26.86)	−0.035	(−0.057, −0.014)	0.001	0.002	(−0.017, 0.021)	0.84
Unknown diabetes (GLU >7.0 mmol/L)	70	18.42 (15.47–22.7)	−0.036	(−0.103, 0.031)	0.285	−0.05	(−0.103, 0.008)	0.093

Adjusted for age, BMI, insulin, smoking status, and alcoholic drinking behavior.
OCN: osteocalcin, hsCRP: high sensitive C-reaction protein, TG: triglycerides, GLU: fasting glucose, BP: blood pressure, HDL-c: high density lipoprotein cholesterol, WC: waist circumference, BMI: body mass index, NGT: normal glucose tolerance, and IFG: impaired fasting glucose.