The Olive Oil-Based Lipid Clinoleic Blocks Leukocyte Recruitment and Improves Survival during Systemic Inflammation: A Comparative In Vivo Study of Different Parenteral Lipid Emulsions

Figure 2

Effect of different lipid compositions on leukocyte recruitment during LPS-induced inflammation. Leukocyte adhesion (a) as number of adherent cells per mm² of surface area and rolling (b) as rolling flux fraction in cremaster muscle venules of mice treated with Clinoleic, Lipofundin, Smoflipid (1 g/kg), or saline (control) were investigated by intravital microscopy 3 h after intrascrotal administration of LPS (50 ng/mouse). Lipids were administered simultaneously with LPS. All values are presented as mean ± SEM from three or more mice per group. Significant differences () to saline-treated mice are indicated by the asterisk.

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