The Olive Oil-Based Lipid Clinoleic Blocks Leukocyte Recruitment and Improves Survival during Systemic Inflammation: A Comparative In Vivo Study of Different Parenteral Lipid Emulsions

<div>Effect of treatment with Lipofundin, Smoflipid, or Clinoleic on lung inflammation during LPS-induced endotoxemia. Lethal endotoxemia was induced by<i> Escherichia coli </i>LPS (serotype 055:B5, 40 mg/kg i.p.) and treated with 2 g/kg Clinoleic (b), Lipofundin (c), Smoflipid (d), or normal saline (control, (a)) at 0.5, 8, and 24 h after LPS challenge. Lungs were harvested 24 h after LPS challenge and prepared as 3 <i>μ</i>m paraffin-embedded sections for H&amp;E staining. Representative micrographs are shown for at least three mice per group. Arrows indicate infiltrating neutrophils. Reference bar for (a)–(d) is shown in (b) and represents 30 <i>μ</i>m.</div>

Mediators of Inflammation

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Figure 3: The Olive Oil-Based Lipid Clinoleic Blocks Leukocyte Recruitment and Improves Survival during Systemic Inflammation: A Comparative In Vivo Study of Different Parenteral Lipid Emulsions 

Figure 3 | The Olive Oil-Based Lipid Clinoleic Blocks Leukocyte Recruitment and Improves Survival during Systemic Inflammation: A Comparative In Vivo Study of Different Parenteral Lipid Emulsions 