The Olive Oil-Based Lipid Clinoleic Blocks Leukocyte Recruitment and Improves Survival during Systemic Inflammation: A Comparative In Vivo Study of Different Parenteral Lipid Emulsions

Figure 8

Lipid-dependent endothelial ICAM-1 and VCAM-1 expression. ICAM-1 (a) and VCAM-1 (b) expression of cultured endothelial cells was measured after stimulation with LPS (100 ng/10⁶ leukocytes/mL) and simultaneous treatment with Lipofundin (I), Smoflipid (II), or Clinoleic (III) (10 mg per 10⁶ leukocytes/mL, 3 h at 37°C). Endothelial ICAM-1 and VCAM-1 expressions were compared to respective isotype and untreated (LPS) and unstimulated (control) controls. Representative histograms are shown for three separate experiments.

(a)

(b)