The Function and Roles of ADAMTS-7 in Inflammatory Diseases

Table 1

Biological characteristics of ADAMTS family members.

Gene	Proteolytic activity	Expression in human tissues	Substrates	Role	References
ADAMTS-1	+	Liver, endotheliocyte, skeletal muscle, and ovary	Aggrecan, versican	Cancer, atherosclerosis, fibrosis, antiangiogenesis, ovarian function, and stress	[81–89]
ADAMTS-2	+	Connective tissue, placenta	Procollagen	Ehlers-Danlos syndrome, mesothelioma, and placenta development	[90–93]
ADAMTS-3	+	Skin, lung, and brain	Procollagen	Dermatosparaxis, osteoarthritis, and lymphangiogenesis	[7, 94, 95]
ADAMTS-4	+	Heart, lung, skeletal muscle, liver, and kidney	Aggrecan, COMP, and brevican	Glioma, atherosclerosis, arthritis, and tendinopathy	[63, 96–99]
ADAMTS-5	+	Macrophage, bladder, oesophagus, and heart	Aggrecan, brevican	Arthritis, cancer	[96, 100, 101]
ADAMTS-6				Tissue repair	[102]
ADAMTS-7	+	Heart, liver, kidney, and skeletal muscle	COMP, α2M	Arthritis, atherosclerosis, and kidney damage	[14, 42, 70, 103]
ADAMTS-8	+	Heart, lung, and kidney	Aggrecan	Cancer, atherosclerosis, arthritis, and antiangiogenesis	[63, 104–106]
ADAMTS-9	+	Heart, lung, and skeletal muscle	Aggrecan, versican	Cancer, atherosclerosis, arthritis, and tissue syndactyly	[107–109]
ADAMTS-10		Lens, cartilage, and skin		Weill-Marchesani syndrome	[110]
ADAMTS-12	+	Chondrocyte, lung, kidney, and liver	COMP, α2M, and aggrecan	Arthritis, cancer, and normal inflammatory response	[14, 54, 111–113]
ADAMTS-13	+	Liver, placenta, heart, and skeletal muscle	von Willebrand factor (vWf)	Thrombotic thrombocytopenic purpura	[9]
ADAMTS-14	+	Collagen-rich tissue, lung, and kidney	Procollagen	Fibrosis, osteoarthritis, tendon disorders, and sclerosis	[114–118]
ADAMTS-15	+	Kidney, lung, heart, ovary, and stem cells	Aggrecan	Cancer, follicle rupture, myogenesis, and spinal injury	[1, 119–122]
ADAMTS-16	+	Lung, kidney, ovary, cartilage, and brain	α2M	Cancer, cryptorchidism, and premature ovarian failure	[22, 123–125]
ADAMTS-17		Epidermis, brain, heart, liver, lung, and prostate		Weill-Marchesani syndrome, short stature, and pediatric stroke	[126–128]
ADAMTS-18		Lung, kidney, liver, brain, and prostate chondrocyte		Ocular disease, cancer, stroke, and bone disorders	[129–133]
ADAMTS-19		Lung, endothelium, ovary	Aggrecan	Premature ovarian failure, osteosarcomas	[134–137]
ADAMTS-20		Ovary, heart, lung, placenta, and testis	Aggrecan	Melanocyte differentiation, pigmentation, and apoptosis	[19, 138]