The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease

Figure 1

The schematic structure of SLAP molecules. SLAP-1 and SLAP-2 contain unique carboxy-terminal sequences, common SH2-SH3 domains and amino-terminals which exist in myristoylated and nonmyristoylated isoforms. SH2 domains help molecules to bind to phosphorylated tyrosine containing epitopes. The SH3 domains connect the proline and hydrophobic amino acid containing molecules.