Low-Dose Steroid Therapy Is Associated with Decreased IL-12 Production in PBMCs of Severe Septic Patients

Table 3

Cytokine responses (pg/mL, mean ± standard error mean) on days 1 and 7 in no-low-dose steroid, low-dose steroid, and control groups.

	No-low-dose steroid; ()	Low-dose steroid; ()	All patients; ()	Controls; ()
Day 1
IL-1	182.0 ± 18.6	200.0 ± 5.6	193.1 ± 7.8	110.8 ± 8.3^†
IL-6	375.0 ± 40.2	416.2 ± 13.8	400.6 ± 17.5	385.4 ± 31.7
IL-10	340.4 ± 84.6	333.1 ± 74.1	335.8 ± 55.1	305.5 ± 29.4
IL-12	514.1 ± 151.8	141.3 ± 39.5	282.7 ± 69.9	266.6 ± 50.5
IL-17	4.7 ± 4.3	2.6 ± 1.3	3.4 ± 1.8	1.0 ± 0.5
TGF-1	26.3 ± 15.3	92.5 ± 28.7	67.4 ± 19.5	36.0 ± 9.9
TNF-	404.9 ± 39.5	279.8 ± 41.2	327.2 ± 31.4	540.8 ± 34.4^†
Day 7
IL-1	189.8 ± 5.8	191.7 ± 5.7^‡	191.9 ± 4.1
IL-6	356.4 ± 35.2	410.3 ± 12.7	389.9 ± 15.9^‡
IL-10	339.3 ± 58.5	237.4 ± 41.0	276.0 ± 34.4
IL-12	1145.7 ± 337.5^‡	269.5 ± 57.7	601.9 ± 152.1^‡
IL-17	0.8 ± 0.4	4.6 ± 1.9	3.2 ± 1.2
TGF-1	25.3 ± 16.2	28.2 ± 11.9^‡	27.1 ± 9.4^‡
TNF-	434.7 ± 14.3	367.1 ± 24.5	392.8 ± 17.1

IL = interleukin; TGF = transforming growth factor; and TNF = tumor necrosis factor.
compared to no-low-dose steroid group, by Mann-Whitney test.
compared to all patients with severe sepsis, by Mann-Whitney test.
compared within the same group on day 1, by Wilcoxon signed-rank test.