Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis

Figure 6

DH recruits more MDSCs to liver and inhibits the infiltration of macrophages in liver. Notes: hepatitis was induced by i.v. injection of ConA (15 mg/kg). Liver mononuclear cells were isolated from mice at 18 h following ConA injection. CD11b⁺ Gr1⁺ MDSCs (a) and CD45⁺ F4/80⁺ Kupffer cells (b) were stained and analyzed by flow cytometer. Numbers in quadrants indicate the percentage of cells in each ((a)(A) and (b)(A)). Proportions of CD11b⁺ Gr1⁺ MDSCs (a)(B) and CD45⁺ F4/80⁺ Kupffer cells (b)(B) among total liver mononuclear cell population (mean SD ; ). ConA: Concanavalin A; DH: Dracocephalum heterophyllum; MDSCs: myeloid-derived suppressor cells.

(a)

(b)