Inhibiting HMGB1 with Glycyrrhizic Acid Protects Brain Injury after DAI via Its Anti-Inflammatory Effect

Figure 2

Dynamic expression of HMGB1 and neuronal apoptosis in rat brains after DAI. HMGB1 was significantly decreased in the first 48 h, with a transient increase at 12 h after DAI (a). TUNEL staining showed a clear neuronal apoptosis from 6 h to 48 h after DAI, with a time-dependent increase. The number of apoptotic cells was expressed as mean ± SD (b). The dynamic changes of the cleavage of caspases 3 and 9 and the phosphorylation of BCL-2 after DAI, detected by immunoblotting (c). compared with sham group.

(a)

(b)

(c)