Correlation of IL-18 with Tryptase in Atopic Asthma and Induction of Mast Cell Accumulation by IL-18

Figure 2

Induction of IL-18 release in the peritoneum of mice by tryptase (Tryp, μg/mL) and agonists of PAR-2. (a) Nonsensitized mice were treated with Tryp with or without its inhibitors Aprotinin (μg/mL) and Leupeptin (μg/mL), tc-LIGRLO-NH₂ (μM), tc-OLRGIL-NH₂ (μM), SLIGRL-NH₂ (μM), LRGILS-NH₂ (μM), or FSLLRY-NH₂ (FSL, μM) for 4 h; (b) OVA-sensitized and nonsensitized mice were treated with Tryp with or without FSL for 2 or 4 h. compared with the corresponding normal saline (NS) group. compared with the corresponding stimulus alone group.

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