Correlation of IL-18 with Tryptase in Atopic Asthma and Induction of Mast Cell Accumulation by IL-18

Figure 3

Flow cytometric analysis of IL-18 (ng/mL) and tryptase (Tryp, μg/mL) induced mast cell (CCR3⁺HLA-DR⁻ cells) accumulation in the peritoneum of OVA-sensitized or nonsensitized mice. ((a) and (c)) Representative graphs of IL-18 and Tryp induced mast cell accumulation; (b) changes in the percentage of mast cells out of total peritoneal cells provoked by IL-18 in the presence or absence of IL-18BP (ng/mL); (d) changes in the percentage of mast cells provoked by Tryp in the presence or absence of FSLLRY-NH₂ (FSL, μM). compared with the corresponding nonsensitized mice. compared with the corresponding normal saline (NS) group. compared with the corresponding stimulus alone group.

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