Correlation of IL-18 with Tryptase in Atopic Asthma and Induction of Mast Cell Accumulation by IL-18

Figure 5

Flow cytometric analysis of tryptase (Tryp, μg/mL) induced expression of IL-18 receptor (IL-18R) on mast cells (CCR3⁺HLA-DR⁻ cells) in the peritoneum of OVA-sensitized or nonsensitized mice. ((a) and (c)) Representative graphs of the proportion of IL-18R⁺ mast cells and mean fluorescence intensity (MFI) of IL-18R on mast cell, respectively; (b) changes in the percentage of IL-18R⁺ mast cells out of total peritoneal mast cells provoked by Tryp in the presence or absence of FSLLRY-NH₂ (FSL, μM); (d) changes in the MFI of IL-18R on mast cell provoked by Tryp. compared with the corresponding nonsensitized mice. compared with the corresponding normal saline (NS) group. compared with the corresponding stimulus alone group.

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