Correlation of IL-18 with Tryptase in Atopic Asthma and Induction of Mast Cell Accumulation by IL-18

Figure 6

Flow cytometric analysis of IL-18 (ng/mL) induced expression of protease activated receptor- (PAR-) 2 on mast cells (CCR3⁺HLA-DR⁻ cells) in the peritoneum of OVA-sensitized or nonsensitized mice. ((a) and (c)) Representative graphs of the proportion of PAR-2⁺ mast cells and mean fluorescence intensity (MFI) of PAR-2 on mast cell, respectively; (b) changes in the percentage of PAR-2⁺ mast cells out of total peritoneal mast cells provoked by IL-18 in the presence or absence of IL-18BP (ng/mL); (d) changes in the MFI of PAR-2 on mast cell provoked by IL-18. compared with the corresponding nonsensitized mice. compared with the corresponding normal saline (NS) group. compared with the corresponding stimulus alone group.

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