Correlation of IL-18 with Tryptase in Atopic Asthma and Induction of Mast Cell Accumulation by IL-18

<div>Flow cytometric analysis of tryptase (Tryp, <i>μ</i>g/mL) induced expression of protease activated receptor- (PAR-) 2 on mast cells (CCR3<sup>+</sup>HLA-DR<sup>−</sup> cells) in the peritoneum of OVA-sensitized or nonsensitized mice. (a) A representative graph of mean fluorescence intensity (MFI) of PAR-2 on mast cell; (b) changes in the MFI of PAR-2 on mast cell provoked by Tryp. <svg height="15.608pt" id="M25" style="vertical-align:-3.833899pt" version="1.1" viewbox="-0.0498162 -11.7741 49.9502 15.608" width="49.9502pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M458 122C446 142 422 163 404 170C370 149 335 141 272 139V142C272 216 281 255 311 281C280 309 275 350 272 418C335 417 370 407 404 387C422 394 447 415 458 436C447 456 424 477 402 484C370 463 335 455 272 453C276 506 282 532 312 584C297 610 275 636 253 647C232 636 208 610 194 584C223 532 230 506 234 453C171 455 136 463 102 484C84 477 60 456 48 436C60 415 84 393 102 387C136 407 171 417 234 418C231 350 226 309 195 281C226 255 231 214 234 139C171 141 136 149 102 170C84 163 60 142 48 122C60 101 84 79 102 72C136 93 171 103 234 104C230 35 224 8 195 -42C208 -69 232 -94 254 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Mediators of Inflammation

fig7

Figure 7

Figure 7: Correlation of IL-18 with Tryptase in Atopic Asthma and Induction of Mast Cell Accumulation by IL-18 