Correlation of IL-18 with Tryptase in Atopic Asthma and Induction of Mast Cell Accumulation by IL-18

Figure 8

IL-18 and tryptase (Tryp) induced IL-4 (a) and thymic stromal lymphopoietin (TSLP) (b) release in the peritoneum of OVA-sensitized or nonsensitized mice. Mice were treated with IL-18 (ng/mL) in the presence or absence of IL-18BP (ng/mL), Tryp (μg/mL) with or without FSLLRY-NH₂ (FSL, μM) for 2 and 4 h before their peritoneal lavage being collected for ELISA analysis. Data were displayed as a boxplot, which indicates the median, interquartile range, the largest and smallest values other than outliers (whiskers). Each piece of data represented a group of 6-7 animals. compared with the corresponding nonsensitized mice. compared with the corresponding normal saline (NS) group. compared with the corresponding stimulus alone group.

(a)

(b)