Serum Cytokines Th1, Th2, and Th17 Expression Profiling in Active Lupus Nephritis-IV: From a Southern Chinese Han Population

Table 3

Serum IL18, IL-18/IL-4, and IL-17A/IL-4 assays using optimal cut-off values.

Assay	Cut-off	Sensitivity	Specificity	AUC	95% CI
IL-18	52.34	0.781	0.882	0.869	0.711–0.968
IL-18/IL-4	26.06	0.563	0.941	0.820	0.700–0.940
IL-17A/IL-4	3.94	0.906	0.471	0.640	0.465–0.815
IL-17A	12.67	0.688	0.706	0.717	0.651–0.873

Performance characteristics of cytokines level in LN-IV. Receiver operating characteristic curve (shown as area under the curve [AUC]) demonstrates the predictive capability of IL-18 level, IL-17A level, IL-18/IL-4 ratio, and IL-17A/IL-4 ratio for the diagnosis of LN-IV. CI: confidence interval.