From Placenta to Polycystic Ovarian Syndrome: The Role of Adipokines

Table 3

Role of adipokines in puberty.

Adipokine	GnRH, LH, and FSH	Estradiol (E2) and testosterone (T)
Adiponectin	AdipoR2 is regulated by the LH receptor function via a cAMP dependent mechanism [132].	T inhibits secretion from adipocytes.; E2 controls oocyte maturation and granulosa cells’ cycle [104, 105].
Leptin	Rises before LH and FSH surge and subsequently declines promoting sexual maturation and pubertal onset.; Induces secretion of GnRH and increases pulsatile activity [116, 117].	Rises before T increase and subsequently declines.; Reduces ovulation inhibiting E2 and T production acting on Leydig cells [118, 119].
Resistin	Not described	Not described
Visfatin	Not described	Not described