Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21

<div>Metformin induced FGF21 production. (a) Electron microscopy of liver tissues from untreated obese mice and metformin-treated obese mice. Scale bars, 2 <i>μ</i>M. (b) CoxIV and FGF21 immunostaining of liver from untreated obese mice and metformin-treated obese mice. Scale bars, 10 <i>μ</i>M. (c) Representative Oil Red O staining in metformin (5 mM) or metformin plus anti-FGF21-treated HepG2 cells.</div>

Mediators of Inflammation

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Figure 3

Figure 3: Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21 