C-Terminal Alpha-1 Antitrypsin Peptide: A New Sepsis Biomarker with Immunomodulatory Function

Figure 7

Receiver operating characteristic (ROC)-curve analysis comparing the test-characteristics of CAAP47/48 and procalcitonin (PCT) for discrimination of patients with severe sepsis () and patients with severe SIRS (polytrauma and cardiac surgery, ). The area under the ROC-curve (AUROC) for CAAP47/48 (0.96) is significantly higher than for PCT (0.62) demonstrating a greater diagnostic accuracy of CAAP47/48 compared to PCT. The optimal cutoff, which is defined to be the concentration at which patients are classified into the SIRS or sepsis group with highest sensitivity and specificity, is 4.9 μM. Severe SIRS and severe sepsis patients can be differentiated with 91.7% specificity and 78.9% sensitivity.