Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism

Figure 1

Induction of mast cell accumulation in peritoneum of mice by compound 48/80 (Comp, μg). Various concentrations of Comp in the presence or absence of leupeptin (Leup, μg) and benzamidine (Benz, μg) were injected in peritoneum of mice for 10 min (a), 3 h (b), 6 h (c), and 16 h (d). Human serum albumin (HSA) was used for foreign protein control, and normal saline (NS) was employed as carrier. Data were displayed as a boxplot, which indicates the median, interquartile range and the largest and smallest values. Each piece of data represented a group of 6-7 animals. compared with the corresponding NS group. compared with the corresponding stimulus alone group.

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