Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism

Figure 2

Induction of mast cell accumulation in peritoneum of mice by tryptase. Various concentrations of recombinant tryptase (rTrypt, μg), lung tryptase (lTrypt, μg), skin tryptase (sTrypt, μg), and trypsin (Tryps, μg) in the presence or absence of FSLLRY-NH₂ (FSLLRY, μM) were injected in peritoneum of mice for 10 min (a), 3 h (b), 6 h (c), and 16 h (d). Normal saline (NS) was employed as carrier. Data were displayed as a boxplot, which indicates the median, interquartile range and the largest and smallest values. Each piece of data represented a group of 6-7 animals. compared with the corresponding NS group. compared with the corresponding stimulus alone group.

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(b)

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