Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism

Figure 3

Induction of mast cell accumulation in peritoneum of mice by agonist peptides of protease activated receptor-2 (PAR-2). Various concentrations of SLIGRL-NH₂ (SLIGRL) and tc-LIGRLO-NH₂ (tc-LIGRLO) and their reverse peptides LRGILS-NH₂ (LRGILS) and tc-OLRGIL-NH₂ (tc-OLRGIL) were injected in peritoneum of mice for 10 min (a), 3 h (b), 6 h (c), and 16 h (d). Normal saline (NS) was employed as carrier. Data were displayed as a boxplot, which indicates the median, interquartile range and the largest and smallest values. Each piece of data represented a group of 6-7 animals. compared with the corresponding NS group.

(a)

(b)

(c)

(d)