Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism

Figure 5

Induction of serotonin release in peritoneum of mice by tryptase. Various concentrations of compound 48/80 (Comp), recombinant tryptase (rTrypt), lung tryptase (lTrypt), and trypsin (Tryps) were injected in peritoneum of mice for 10 min (a) and 3 h (b). Human serum albumin (HSA) was used for foreign protein control, and normal saline (NS) was employed as carrier. Data were displayed as a boxplot, which indicates the median, interquartile range and the largest and smallest values. Each piece of data represented a group of 6-7 animals. compared with the corresponding NS group.

(a)  

(b)