Imiquimod Treatment Causes Systemic Disease in Mice Resembling Generalized Pustular Psoriasis in an IL-1 and IL-36 Dependent Manner

Figure 1

Generic imiquimod cream causes more severe disease than Aldara®. Male C57BL/6J mice ( per group) received daily treatments (a) with Aldara (black symbols) or generic (Perrigo®, open symbols) 5% imiquimod cream (62.5 mg). Weight ((b), expressed as percentage of values at day 0), survival (c), and skin inflammation (d) were monitored. Data from one representative experiment of at least 3 independent experiments is shown as means SD. ; (comparing Generic to Aldara at individual timepoints).

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