12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis

Table 5

Circulating Treg subsets are not affected by long-term physical exercise in MS.

Treg subset	Group	Time	Mean % Treg in CD4^+ T cell population ± SEM	P values
CD2FoxP3^+	EX	PRE	0.62 ± 0.11	0.083
		POST	1.12 ± 0.41
	SED	PRE	1.00 ± 0.30	0.782
		POST	1.69 ± 0.85
IL-10^+ (Tr1)	EX	PRE	0.22 ± 0.05	1.000
		POST	0.20 ± 0.02
	SED	PRE	0.33 ± 0.09	0.796
		POST	0.50 ± 0.26
TGF-β^+ (Th3)	EX	PRE	0.15 ± 0.02	1.000
		POST	0.19 ± 0.09
	SED	PRE	0.17 ± 0.04	0.056
		POST	0.12 ± 0.08

The percentage of circulating Treg subsets was determined using flow cytometry. Results are shown as mean percentage ± SEM.
Treg, regulatory T cell; FoxP3, forkhead box P3; IL, interleukin; Tr1, type 1 regulatory T cell; TGF, transforming growth factor; Th3, T helper 3 cell; EX, exercise group; SED, sedentary control group; PRE, baseline measurement; POST, measurement after 12 weeks; SEM, standard error of the mean.