Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like Synoviocytes

Figure 6

Cytokine modulation in RA-FLSs. IL15: RA-FLSs were grown in tissue medium (TM) or in synovial fluid (SF) for 5 days. Smac127 (15 μM) was added for 24 hrs. The data were generated with Odyssey infrared platform. In Cell Western with 800 channels we detected the cytokine production. Data are expressed as In Cell Western relative data (ICW relative). We analysed the production of IL-15, IL-6, IL-10, MMP-1, RANKL, and OPG. The histograms summarize the mean ± SD of the ten independent experiments. versus untreated cells.